
Pharmaceutical product development

Publications:
Water as modifier of the DMSO-CO2 phase behaviour: new approach for polymer micronization using the PCA proces., Perez de Diego, Y, Pellikaan, H, Wubbolts, FE, Wiggenhorn, M, Borchard, G, Witkamp, GJ, Jansens, PJ, (2004), Proceedinges of the 9th Meeting on Supercritical Fluids, Trieste, Italy (2004)
Production of L-PLA microparticles below and above the mixture critical pressure of the system DCM-CO2., Perez de Diego, Y, Pellikaan, H, Wubbolts, FE, Witkamp, GJ, Jansens, PJ, (2004), Proceedings of the 9th Meeting on Supercritical Fluids, Trieste, Italy (2004)
Operating regimes and mechanism of particle formation during the precipitation of polymers using the PCA process, J. Supercrit. Fluids, 35, 147-156, 2005
Y. Perez de Diego, H.C. Pellikaan, F.E. Wubbolts, G.J. Witkamp, P.J. Jansens
Opening new operating windows for polymer and protein micronisation using the PCA process J. of Supercritical Fluids 36, 216-224, 2006 Y. Perez de Diego, H.C. Pellikaan, F.E. Wubbolts, G. Borchard, G.J. Witkamp, P.J. Jansens
Nozzle construction for particle formation using super critical anti solvent precipitation Hubert C. Pellikaan, Frank E. Wubbolts, Proceedings of the 6th Meeting on Supercritical Fluids, Versailles (April 2003)
Microparticles prepared in supercritical fluids as inhalable drug delivery system. Pellikaan H.C, Smits P.J., Borchard G., Wiggenhorn M., Yuasa H.,
Proceedings of the 6th Meeting on Supercritical Fluids, VERSAILLES (April 2003)
Intratracheal administration of insulin dry powder formulation using N-trimethyl chitosan as an absorption enhancer. M. Amidi, H. Pellikaan, W. Hennink, D. Crommelin, W. Jiskoot
Proc. 5th World Meeting on Pharmaceutics, Biopharmaceuticsw and Pharmaceutical Technology, Geneva, march 2006
Application of Near- and Supercritical Fluids to Dry Aqueous Liposomal Formulations
M. Wiggenhorn, H.C. Pellikaan, G. Winter. Proc. 5th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, march 2006
Neuroprotection in Parkinson's Disease: A Systematic Review of the Preclinical Data
Hidde Douna, Bas Bavelaar, Hubert Pellikaan, Toine Pieters. Bentham Open Science, Pp 12-26, 09 May, 2012
​
Toon van der Gronde, Anita Hartog, Charlotte van Hees, Hubert Pellikaan, Toine Pieters
December 2015 Food Chemistry
​
Nicotinamide is a potent uptake enhancer in nasal drug delivery. July 2017 BIT BBBS 2017 july 12 - 14 2017
​
Antibiotic free treatment of hotspots with FURNER®,
April 2019, European Veterinary Conference Voorjaarsdagen, Hubert Pellikaan, Dirk Becking, Evert Jan de Boer, Robert van Meer
Patents:
Filed in 2021:
​
Nasal spray formulation of a diuretic drug
​
Nasal spray that blocks viral infection via the nasal mucosa
​
Method for preparing a tissue-adhesive powder
​
Published patents and patent application
WO 2021/009016
Onderwerp: METHOD FOR PREPARING A TISSUE-ADHESIVE SHEET
​
WO2021177815 (A1)
DISPENSING SYSTEM FOR USE IN CRYOGENIC SKIN TREATMENT
BR112020001098 (A2)
METHOD FOR PREPARING A TISSUE-ADHESIVE SHEET
WO2021009016 (A1)
INTRANASAL ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBSTANCES
ZA201905963 (B)
WO2020148318 (A1)
PL2063861 (T3)
PL2061427 (T3)
Nebulizer and Spacer for the Topical Application of a Liquid and/or Solid to a Surface
US2017189627 (A1)
DK2892517 (T3)
Anchor of a clock or watch movement that is balanced or poised with the aid of a counterweight.
NL1041281 (A)
STERILE ALGINATE-BASED AQUEOUS COMPOSITION FOR MEDICAL USE AND PROCESS FOR THE PREPARATION THEREOF
ES2531669 (T3)
ENHANCED NAIL PENETRATING COMPOSITION
EP2908860 (A1)
TW200637111 (A)
STERILE ALGINATE-BASED AQUEOUS COMPOSITION FOR MEDICAL USE AND PROCESS FOR THE PREPARATION THEREOF
EP2747760 (A1)
IN SITU GELLING ALGINATE SYSTEMS
EP2416741 (A1)
Preparation of powders containing colloidal particles
AT440594 (T)
Process for small particle formation
US2005206022 (A1)
METHOD FOR PARTICLE PRECIPITATION USING NEAR-CRITICAL AND SUPERCRITICAL ANTISOLVENTS
WO2004006893 (A1)
A METHOD OF PROCESSING LIPID MATERIALS
WO02102947 (A1)
​